Benefit of Rejuvenation
The rejuvenation program that I present to patients is a process of rebooting cells to function optimally. This is done by replacing or restoring proteins, growth factors, enzymes, and other biologic substances that are used by cells for optimal function, repair, and regeneration.
- If you are 50 years of age, understand that many of the biologic substances for metabolism in your cells have diminished or become depleted. Much of this happens in a very subtle way. You do not have to go to the emergency room and society accepts “you are just getting older.” However, rejuvenation is possible. This is true biohacking, not using drugs or plastic surgery.
- In cases of chronic disease with multiple symptoms patients may have innumerable office visits and treatments from many subspecialists. A rebooting process can eliminate many of the symptoms because cells function more optimally. After rejuvenation, a more simple and straightforward program for further recovery can be presented to these patients. The cells are functioning better. An overhaul rather than oil change. Biohacking.
I spent 29 years in a solo practice doing cardiovascular surgery near Kansas City. I also obtained a doctorate in natural medicine, giving me a wide background and experience with over 47 years in both conventional as well as alternative medical practices. During my surgical career I learned the preoperative evaluation. I operated or helped operate on every part of the body. As a surgeon I was involved with the postop healing process. We had no hospitalists at that time and I rounded on most of my patients twice a day and intensive care unit patients several times a day. There was no dressing team. I took care of the wounds daily. Principles learned as a surgeon regarding wound healing are a basic part of my practice including stem cell treatment.
https://www.linkedin.com/pulse/stem-cell-therapy-my-experience-optimal-results-using-joseph-edward/
Regenerative therapy is boosted by using principles of wound healing.
Practicing age management in New York City the last 12 years, I quickly found that getting older means body parts wear out. Working with retired NFL and NBA players I began doing stem cell treatment for joint and soft tissue injuries. Then I started treating military members and with this group began dealing with other conditions such as traumatic brain injury, MS, emphysema and lung problems, autoimmune disorders, and liver problems as well as regeneration from various soft tissue and joint injuries. Look at the human machine not just a body part.
Bio hacking is my game plan. From my surgical background, this is all a matter of wound healing. Agents used in rejuvenation treatment are part of normal biologic substances present, but depleted, in our system. Then wound healing occurs-- the body wants to heal itself.
As the first step, optimization of the patient’s chemical and hormone status can be done to promote regeneration and healing. Light and oxygen are also used as part of wound healing. Interval reappraisal of the patient directs further recommendations for regeneration of tissue. This is where various peptides have come into play as part of the overall picture.
https://www.linkedin.com/pulse/peptidesa-summary-joseph-edward-bosiljevac-jr-md-phd-facs-1f/
BPC 157 is one of the most frequently used. The military guys and retired professional players have been beat up all over. General use of this peptide for soft tissue and joint problems has certainly been extremely helpful. If the patient has a specific joint issue or a tendonitis such as tennis elbow, they can be instructed to give the injection (subcutaneous like an insulin shot) around any bothersome area. There is a high initial local tissue concentration before the peptide is absorbed systemically. This can rapidly improve results over an acute or chronically diseased area. I have seen this clear tennis elbow pain within two weeks. A peptide such as BPC 157 is usually used short-term for 1 to 3 months. This is basically giving fertilizer to the human machine to repair itself. My experience has been gained by looking at the entire patient and then doing a “wound inspection” and dressing change.
An interesting note is that BPC 157 is a peptide of gastrointestinal origin. Many chronic gastrointestinal complaints like acid reflux and irritable bowel symptoms disappear within a couple of weeks after initiating this peptide even though it was given for a musculoskeletal problem. In most patients I have seen a definite gastrointestinal benefit despite giving the peptide for another reason.
Case report
A 58-year-old Navy SEAL was seen three months after his “brain quit.” His history revealed multiple concussions which include a fall from rock climbing and multiple blast injuries. He was initially institutionalized and started on hyperbaric oxygen treatment, showing some improvement after 20 treatments.
On my exam his mental clarity and focus were blunted. He had bilateral tinnitus and intermittent dizziness. Speech was sluggish and at times a little slurred. There was a degenerative condition of both knees and his low back due to years of packing a lot of weight while on deployment as well as parachute drops. He had left sacroiliac impingement as a component of the back pain.
About a month postop from a partial left knee replacement he hyperextended it stepping down. The left quadriceps at the distal femoral attachment was painful and suggested an acute partial tendon tear. There was pain in the left shoulder with tenderness over the biceps insertion but full range of motion of the shoulder itself was maintained. The patient also has a history of chronic acid peptic disease.
All portions of the program are to reboot cells and improve metabolism to what it was years before.
https://www.linkedin.com/pulse/what-does-mean-reboot-joseph-edward-bosiljevac-jr-md-phd-facs/
The first part is to initiate chemical and hormone optimization. The patient was started on bioidentical testosterone which promotes repair and rebuilding with wound healing.
Following this, the patient had two days of intravenous NAD (nicotinamide adenosine dinucleotide) infusions. Recall that diseased and affected nerve tissue dumps out NAD.
https://medicine.wustl.edu/news/surprising-culprit-nerve-cell-damage-identified/
Then neuropathies develop. During the NAD infusion there was improvement of the tinnitus as well as the speech.
https://www.linkedin.com/pulse/therapeutic-use-nad-joseph-edward-bosiljevac-jr-md-phd-facs/
I have many MS patients who had significant improvement in neurologic symptoms with NAD given intravenously. This is only temporary--you are filling up the NAD gas tank. However, it also indicates that stem cell therapy can give long-standing benefit. When patients improve dramatically with the IV infusion of NAD I am confident and optimistic they will respond favorably with stem cells given in a wound healing environment.
On the third day intravenous exosomes (growth factors) and umbilical cord stem cells were infused systemically. This was done using wound healing adjuncts such as infrared laser to stimulate nitric oxide production and hyperoxygenation. I also performed an exosome injection into the distal left quadriceps.
Finally, the patient was started on the peptide BPC 157 as a subcutaneous injection. He was given an initial course to last about two months.
https://bengreenfieldfitness.com/article/supplements-articles/how-to-use-bpc-157/
Within a week the patient told me that mentally he was better than he remembers for 10 years. He continues to get positive feedback from family and friends as far as his mental status and speech. After a month all his body aches were gone. He was doing pull-ups with the biceps with no problem. The knee was pain free. The vertigo was not completely relieved but it was improved. An interesting aspect is that his acid reflux was gone.
The patient had an initial SPEC scan of the head in October 2019 which showed very poor cerebral circulation and decreased function in multiple portions of the brain. One month after his described treatment here in NYC, a repeat SPEC scan showed marked improvement in cerebral function and circulation. In fact, several radiologists at the imaging center had never seen such rapid improvement in any patient. And this correlates very much with the patient’s subjective reports.
The top image is pretreatment and the bottom post the described treatment.
Blue indicates no perfusion, green minimal and yellow optimal blood flow.
The red on cerebellum shows optimal output.
The bottom scans show significant improvement in blood flow and brain function.
What does this mean? I am not a miracle worker. Restore the cells to work more normally. Simple, but not accepted in conventional medicine.
Then reassess the patient and develop a further game plan. The body wants to heal itself.
I adjust the dose of the BPC 157 depending on the patient’s presentation during the healing process. A longer course of the BPC 157 could be used or another peptide instituted down the line. Other patients given the BPC 157 have also reported improvement in gastrointestinal symptoms, and the acid peptic complaints disappeared in this case. I will continue him with BPC 157 for two more months.
Basically, the philosophy is rebooting the cells to work normally. Peptides play a part. In addition, so is the use of biologically active NAD, exosomes, and sometimes stem cells. Regeneration leads to rejuvenation. Cells function more optimally. Rebooting cells is more than just an oil change. This is an overhaul. Personal maintenance is so important.
Peptides can be a part of the wound healing process themselves or combined with stem cell therapy. My practice is not one that patients come in to get a shot of stem cells and receive a bill. I monitor the patient many times through one or two years as we go through rehabilitation and direct their treatment based on the personal healing response. Peptides can be an active part of this. Biohacking-- using normal and natural bio chemicals, not drugs or plastic surgery.
The other common peptide that is used in my rejuvenation program is epitalon. I have one patient who nine the years ago had a baseline chronological age of 62 and a biologic age of 56 using telomere measurement. The next six years three short courses of epitalon were given. NAD, exsomes, and stem cells were also used. With a chronologic age of 70 the patient’s biologic age was 54 using the same telomere measurement. Biologically younger --or the same, good deal!
See my photo-age 70.
And it is important to keep these experienced 55-year-old military guys going strong. They allow us to all sleep in bed at night!