The Therapeutic Use of NAD

Submitted by admin on Wed, 06/12/2019 - 09:24
Dr. Joseph Bosiljevac, Jr, MD, PhD, FACS
Joseph Bosiljevac, Jr, MD, PhD, FACS


NAD is an essential metabolite in our biologic system. It is found in cells in the mitochondria and encourages ATP to produce energy. With sufficient energy the cell functions optimally. NAD is used in every cell in the body that has mitochondria. Clinically, NAD treatment has shown benefit in patients with chronic alcoholism and drug addiction. A course can markedly decrease or eliminate cravings.

After age 50 it has been demonstrated that NAD levels continue to decrease significantly in most of us. This leads to fatigue because cell energy production is diminished.

  1. This can affect the surtuin protein family, which helps improve mitochondrial function and serves an antiaging purpose.
  2. NAD infusions increase telomere length.
  3. NAD infusions improve neurotransmitter levels.
  4. Biologic enzyme processes are overall improved.


NAD can be given in many forms. By mouth it has to be a component of nicotinic acid. Pushing this at high levels causes hot flashes and other symptoms that patients do not like. Patches and creams can be used or even a nasal spray.


My preference is intravenous infusion. With this route we know the medication is getting directly into the bloodstream.


The infusion itself takes in the range of about four hours. This can be performed in an office or at a patient’s home. Preferential treatment would be an initial IV of a Myers cocktail, methylcobalamine (B12) and glutathione. Once this is infused then anywhere from 500 to 1000 milligrams of NAD can be administered intravenously.


NAD encourages biologic activities that involve methylation. This is a word referring to how the body is metabolizing substances.

Trimethyl glycine (betaine) provides a good methyl donor and can be taken as an oral supplement. This is a good methylator which can lower homocysteine levels. Otherwise, additional oral magnesium, calcium, and potassium are helpful.


Any symptoms to the NAD infusion are temporary (this is a normal biologic product). The IV needs to be administered at a rate that takes about four hours since faster infusion can bring on uncomfortable but not life-threatening side effects such as dizziness and chest tightness. These are eliminated by controlling the rate of infusion. Occurrence varies depending on the patient. It is interesting that alcoholics will rapidly soak up lots of NAD with no adverse side effects. They are severely depleted. The liver is an organ that requires a lot of NAD.

NAD alone can be used for many chronic neurodegenerative conditions. In combination with stem cells further improvement has been seen with:

  1. multiple sclerosis
  2. Parkinson’s disease
  3. Alzheimer’s
  4. post stroke
  5. traumatic brain injury
  6. chronic degenerative neuromuscular diseases
  7. peripheral neuropathy

NAD can be combined with stem cells for rejuvenation.


A doctor and IV team needs to be certified to prescribed and administer NAD for medical treatment. Not every doctor can administer this.

It is also important for the physician to be stem cell certified.